ABSTRACT
Objective To explore clinical features,prognosis and study related cancer types in patients with familial gastric carcinoma. Methods Nine families of ICG-HGC and 3 families of suspected-ICG-HGC according with International Collaborative Group on Hereditary Gastric Cancer standard were collected and their pedigree trees were drawn.Clincial features and prognosis of ICG-HGC and suspected-ICG-HGC families were analyzed.and the related cancer types of ICG-HGC and suspected-ICG-HGC kindreds were investigated. Resuits The morbidity of ICG-HGC and suspected-ICG-HGC was 0.99%;The age of patients among the propositi of 12 kindreds were 29～65 years old with the mean age of 56 years old.Among 11 kindreds,there were 45 cases of cancers including 2 cases of multiple cancers.There were 30 foci of gastric cancer,most of which were located in lower and middle third of the stomach,with pathologic type of adenocarcinoma in poor to moderate differentiation.There were totally 15 extrastomach tumors including 7 colorectal cancers.Four cases of 11 kindreds had survived for 3 years including 1 case surviving for more than 10 years. Conclusion The familial gastric cancers in southern China have special characteristics such as poorly pathologic differentiation,advanced cancer stage,early age of onset,distal end of the stomach in location and high incidence of related tumors in colorectum.
ABSTRACT
Purpose:To explore the relationship between genetic polymorphisms of p53 codon72 and the risk of gastric cancer.Methods:A population based case control study was conducted in Taixing, Jiangsu Province, China, and 204 gastric cancer cases and 415 controls were collected. Results:Distribution of Pro/Pro genotype in cancer cases was significantly higher than controls. The OR and 95%CI of Pro/Pro or Pro/Arg genotype was 1.5 (1.01～2.23) compared with Arg/Arg genotype. Pro/Pro or Pro/Arg genotype may interact with cigarette smoking, alcohol drinking, river water drinking and high salt food intake. Conclusions:Pro genotype may be related with the risk of gastric cancer and may also interact with environmental risk factors to increase the risk of gastric cancer.